Autoactive alleles of the flax L6 rust resistance gene induce non-race-specific rust resistance associated with the hypersensitive response.
Identifieur interne : 000160 ( Main/Exploration ); précédent : 000159; suivant : 000161Autoactive alleles of the flax L6 rust resistance gene induce non-race-specific rust resistance associated with the hypersensitive response.
Auteurs : Paul Howles [Australie] ; Greg Lawrence ; Jean Finnegan ; Helen Mcfadden ; Michael Ayliffe ; Peter Dodds ; Jeff EllisSource :
- Molecular plant-microbe interactions : MPMI [ 0894-0282 ] ; 2005.
Descripteurs français
- KwdFr :
- Allèles (MeSH), Données de séquences moléculaires (MeSH), Feuilles de plante (croissance et développement), Feuilles de plante (génétique), Feuilles de plante (microbiologie), Immunité innée (génétique), Lin (croissance et développement), Lin (génétique), Lin (microbiologie), Maladies des plantes (génétique), Maladies des plantes (microbiologie), Mutagenèse dirigée (MeSH), Mutation (MeSH), Phénotype (MeSH), Protéines végétales (génétique), Régions promotrices (génétique) (génétique), Séquence conservée (génétique), Séquence d'acides aminés (MeSH), Végétaux génétiquement modifiés (MeSH).
- MESH :
- croissance et développement : Feuilles de plante, Lin.
- génétique : Feuilles de plante, Immunité innée, Lin, Maladies des plantes, Protéines végétales, Régions promotrices (génétique), Séquence conservée.
- microbiologie : Feuilles de plante, Lin, Maladies des plantes.
- Allèles, Données de séquences moléculaires, Mutagenèse dirigée, Mutation, Phénotype, Séquence d'acides aminés, Végétaux génétiquement modifiés.
English descriptors
- KwdEn :
- Alleles (MeSH), Amino Acid Sequence (MeSH), Conserved Sequence (genetics), Flax (genetics), Flax (growth & development), Flax (microbiology), Immunity, Innate (genetics), Molecular Sequence Data (MeSH), Mutagenesis, Site-Directed (MeSH), Mutation (MeSH), Phenotype (MeSH), Plant Diseases (genetics), Plant Diseases (microbiology), Plant Leaves (genetics), Plant Leaves (growth & development), Plant Leaves (microbiology), Plant Proteins (genetics), Plants, Genetically Modified (MeSH), Promoter Regions, Genetic (genetics).
- MESH :
- chemical , genetics : Plant Proteins.
- genetics : Conserved Sequence, Flax, Immunity, Innate, Plant Diseases, Plant Leaves, Promoter Regions, Genetic.
- growth & development : Flax, Plant Leaves.
- microbiology : Flax, Plant Diseases, Plant Leaves.
- Alleles, Amino Acid Sequence, Molecular Sequence Data, Mutagenesis, Site-Directed, Mutation, Phenotype, Plants, Genetically Modified.
Abstract
L6 is a nucleotide binding site-leucine rich repeat (NBS-LRR) gene that confers race-specific resistance in flax (Linum usitatissimum) to strains of flax rust (Melampsora lini) that carry avirulence alleles of the AvrL567 gene but not to rust strains that carry only the virulence allele. Several mutant and recombinant forms of L6 were made that altered either the methionine-histidine-aspartate (MHD) motif conserved in the NBS domain of resistance proteins or exchanged the short domain C-terminal to the LRR region that is highly variable among L allele products. In transgenic flax some of these alleles are autoactive; they cause a gene dosage-dependent dwarf phenotype and constitutive expression of genes that are markers for the plant defense response. Their effects and penetrance ranged from extreme to mild in their degree of plant stunting, survival, and reproduction. Dwarf plants were also resistant to flax rust strains virulent to wild-type L6 plants, and this nonspecific resistance was associated with a hypersensitive response (HR) at the site of rust infection. The strongest autoactive allele, expressed in Arabidopsis from an ethanol-inducible promoter, gave rise to plant death dependent on the enhanced disease susceptibility 1 (EDS1) gene, which indicates that the mutant flax (Linaceae) L6 gene can signal cell death through a defined disease-resistance pathway in a different plant family (Brassicaceae).
DOI: 10.1094/MPMI-18-0570
PubMed: 15986927
Affiliations:
Links toward previous steps (curation, corpus...)
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sort="Mcfadden, Helen" uniqKey="Mcfadden H" first="Helen" last="Mcfadden">Helen Mcfadden</name></author><author><name sortKey="Ayliffe, Michael" sort="Ayliffe, Michael" uniqKey="Ayliffe M" first="Michael" last="Ayliffe">Michael Ayliffe</name></author><author><name sortKey="Dodds, Peter" sort="Dodds, Peter" uniqKey="Dodds P" first="Peter" last="Dodds">Peter Dodds</name></author><author><name sortKey="Ellis, Jeff" sort="Ellis, Jeff" uniqKey="Ellis J" first="Jeff" last="Ellis">Jeff Ellis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15986927</idno><idno type="pmid">15986927</idno><idno type="doi">10.1094/MPMI-18-0570</idno><idno type="wicri:Area/Main/Corpus">000164</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000164</idno><idno type="wicri:Area/Main/Curation">000164</idno><idno type="wicri:explorRef" wicri:stream="Main" 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first="Jean" last="Finnegan">Jean Finnegan</name></author><author><name sortKey="Mcfadden, Helen" sort="Mcfadden, Helen" uniqKey="Mcfadden H" first="Helen" last="Mcfadden">Helen Mcfadden</name></author><author><name sortKey="Ayliffe, Michael" sort="Ayliffe, Michael" uniqKey="Ayliffe M" first="Michael" last="Ayliffe">Michael Ayliffe</name></author><author><name sortKey="Dodds, Peter" sort="Dodds, Peter" uniqKey="Dodds P" first="Peter" last="Dodds">Peter Dodds</name></author><author><name sortKey="Ellis, Jeff" sort="Ellis, Jeff" uniqKey="Ellis J" first="Jeff" last="Ellis">Jeff Ellis</name></author></analytic><series><title level="j">Molecular plant-microbe interactions : MPMI</title><idno type="ISSN">0894-0282</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles (MeSH)</term><term>Amino Acid Sequence (MeSH)</term><term>Conserved Sequence 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développement)</term><term>Lin (génétique)</term><term>Lin (microbiologie)</term><term>Maladies des plantes (génétique)</term><term>Maladies des plantes (microbiologie)</term><term>Mutagenèse dirigée (MeSH)</term><term>Mutation (MeSH)</term><term>Phénotype (MeSH)</term><term>Protéines végétales (génétique)</term><term>Régions promotrices (génétique) (génétique)</term><term>Séquence conservée (génétique)</term><term>Séquence d'acides aminés (MeSH)</term><term>Végétaux génétiquement modifiés (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Plant Proteins</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Feuilles de plante</term><term>Lin</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conserved Sequence</term><term>Flax</term><term>Immunity, Innate</term><term>Plant Diseases</term><term>Plant Leaves</term><term>Promoter Regions, Genetic</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Flax</term><term>Plant Leaves</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Feuilles de plante</term><term>Immunité innée</term><term>Lin</term><term>Maladies des plantes</term><term>Protéines végétales</term><term>Régions promotrices (génétique)</term><term>Séquence conservée</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Feuilles de plante</term><term>Lin</term><term>Maladies des plantes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Flax</term><term>Plant Diseases</term><term>Plant Leaves</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Amino Acid Sequence</term><term>Molecular Sequence Data</term><term>Mutagenesis, Site-Directed</term><term>Mutation</term><term>Phenotype</term><term>Plants, Genetically Modified</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Données de séquences moléculaires</term><term>Mutagenèse dirigée</term><term>Mutation</term><term>Phénotype</term><term>Séquence d'acides aminés</term><term>Végétaux génétiquement modifiés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">L6 is a nucleotide binding site-leucine rich repeat (NBS-LRR) gene that confers race-specific resistance in flax (Linum usitatissimum) to strains of flax rust (Melampsora lini) that carry avirulence alleles of the AvrL567 gene but not to rust strains that carry only the virulence allele. Several mutant and recombinant forms of L6 were made that altered either the methionine-histidine-aspartate (MHD) motif conserved in the NBS domain of resistance proteins or exchanged the short domain C-terminal to the LRR region that is highly variable among L allele products. In transgenic flax some of these alleles are autoactive; they cause a gene dosage-dependent dwarf phenotype and constitutive expression of genes that are markers for the plant defense response. Their effects and penetrance ranged from extreme to mild in their degree of plant stunting, survival, and reproduction. Dwarf plants were also resistant to flax rust strains virulent to wild-type L6 plants, and this nonspecific resistance was associated with a hypersensitive response (HR) at the site of rust infection. The strongest autoactive allele, expressed in Arabidopsis from an ethanol-inducible promoter, gave rise to plant death dependent on the enhanced disease susceptibility 1 (EDS1) gene, which indicates that the mutant flax (Linaceae) L6 gene can signal cell death through a defined disease-resistance pathway in a different plant family (Brassicaceae).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15986927</PMID><DateCompleted><Year>2005</Year><Month>10</Month><Day>27</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0894-0282</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>6</Issue><PubDate><Year>2005</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Molecular plant-microbe interactions : MPMI</Title><ISOAbbreviation>Mol Plant Microbe Interact</ISOAbbreviation></Journal><ArticleTitle>Autoactive alleles of the flax L6 rust resistance gene induce non-race-specific rust resistance associated with the hypersensitive response.</ArticleTitle><Pagination><MedlinePgn>570-82</MedlinePgn></Pagination><Abstract><AbstractText>L6 is a nucleotide binding site-leucine rich repeat (NBS-LRR) gene that confers race-specific resistance in flax (Linum usitatissimum) to strains of flax rust (Melampsora lini) that carry avirulence alleles of the AvrL567 gene but not to rust strains that carry only the virulence allele. Several mutant and recombinant forms of L6 were made that altered either the methionine-histidine-aspartate (MHD) motif conserved in the NBS domain of resistance proteins or exchanged the short domain C-terminal to the LRR region that is highly variable among L allele products. In transgenic flax some of these alleles are autoactive; they cause a gene dosage-dependent dwarf phenotype and constitutive expression of genes that are markers for the plant defense response. Their effects and penetrance ranged from extreme to mild in their degree of plant stunting, survival, and reproduction. Dwarf plants were also resistant to flax rust strains virulent to wild-type L6 plants, and this nonspecific resistance was associated with a hypersensitive response (HR) at the site of rust infection. The strongest autoactive allele, expressed in Arabidopsis from an ethanol-inducible promoter, gave rise to plant death dependent on the enhanced disease susceptibility 1 (EDS1) gene, which indicates that the mutant flax (Linaceae) L6 gene can signal cell death through a defined disease-resistance pathway in a different plant family (Brassicaceae).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Howles</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>CSIRO, Plant Industry, GPO Box 1600, Canberra ACT 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawrence</LastName><ForeName>Greg</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Finnegan</LastName><ForeName>Jean</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>McFadden</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Ayliffe</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Dodds</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Ellis</LastName><ForeName>Jeff</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Plant Microbe Interact</MedlineTA><NlmUniqueID>9107902</NlmUniqueID><ISSNLinking>0894-0282</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C095731">L6 protein, Linum usitatissimum</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017124" MajorTopicYN="N">Conserved Sequence</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019597" MajorTopicYN="N">Flax</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016297" MajorTopicYN="N">Mutagenesis, Site-Directed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018515" MajorTopicYN="N">Plant Leaves</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>7</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>10</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>7</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15986927</ArticleId><ArticleId IdType="doi">10.1094/MPMI-18-0570</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Ayliffe, Michael" sort="Ayliffe, Michael" uniqKey="Ayliffe M" first="Michael" last="Ayliffe">Michael Ayliffe</name><name sortKey="Dodds, Peter" sort="Dodds, Peter" uniqKey="Dodds P" first="Peter" last="Dodds">Peter Dodds</name><name sortKey="Ellis, Jeff" sort="Ellis, Jeff" uniqKey="Ellis J" first="Jeff" last="Ellis">Jeff Ellis</name><name sortKey="Finnegan, Jean" sort="Finnegan, Jean" uniqKey="Finnegan J" first="Jean" last="Finnegan">Jean Finnegan</name><name sortKey="Lawrence, Greg" sort="Lawrence, Greg" uniqKey="Lawrence G" first="Greg" last="Lawrence">Greg Lawrence</name><name sortKey="Mcfadden, Helen" sort="Mcfadden, Helen" uniqKey="Mcfadden H" first="Helen" last="Mcfadden">Helen Mcfadden</name></noCountry><country name="Australie"><noRegion><name sortKey="Howles, Paul" sort="Howles, Paul" uniqKey="Howles P" first="Paul" last="Howles">Paul Howles</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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